红髓原体为血管提供内皮细胞
Alice Plein1, Alessandro Fantin1, Laura Denti1
1UCL Institute of Ophthalmology, University College London, London, UK.
Nature
|September 28, 2018
概括
胚胎血管从以前未知来源的红骨髓原细胞 (EMP) 获得新的内皮细胞. 这一发现揭示了哺乳动物血管扩张的双重机制.
科学领域:
- 发育生物学
- 血液形成
- 血管生物学
背景情况:
- 胚胎血管是由血管细胞分化成内皮细胞形成的.
- 以前认为内皮细胞扩张仅通过增殖发生.
研究的目的:
- 研究胚胎血管发育的内皮细胞的替代来源.
- 鉴定红色骨髓原体 (EMP) 对血管化的贡献.
主要方法:
- 追踪红色骨髓原体的分化和迁移.
- 分析EMPs对黄囊和胚胎内血管的贡献.
主要成果:
- 电磁波的第一个波将导致黄囊内皮.
- 电磁波的第二波殖民胚胎, 形成胚胎内皮,
- 电磁波是一个新的内皮细胞来源.
结论:
- 胚胎血液血管内皮通过双重机制扩张.
- 这涉及现有的内皮细胞的增殖和由造血前体 (EMP) 衍生的细胞的结合.
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