用为模板的半结构抗菌剂的单水热合成
Viktor Dubovoy1, Anjani Ganti2, Tao Zhang2
1Department of Chemistry and Chemical Biology , Rutgers, The State University of New Jersey , Piscataway , New Jersey 08854 , United States.
Journal of the American Chemical Society
|September 28, 2018
概括
新型的二氧化微粒可以为抗菌用途提供化 (BAC). 这些材料显示pH反应药物释放,有效降低细菌活力,有助于消毒剂的应用.
科学领域:
- 材料科学
- 纳米技术
- 制药科学
背景情况:
- 半孔二氧化微粒提供了可控药物输送的潜力.
- 化 (BAC) 是一种广泛使用的抗菌剂.
- 开发有效的抗菌药物输送系统对于制药和食品行业至关重要.
研究的目的:
- 合成和描述用于抗菌药物输送的新型中等孔微粒.
- 调查药物载荷能力,孔隙结构,以及从微粒中释放BAC的动力学.
- 评估含有BAC的微粒对金黄色葡萄球菌和沙门氏菌的抗菌效果.
主要方法:
- 半孔微粒的合成和表征.
- 将化 (BAC) 装入二氧化.
- 小角度X射线衍射 (SAXRD) 和巴雷特-乔纳-哈伦达 (BJH) 分析孔隙结构.
- 在不同pH值下进行体外药物释放研究.
- 微生物学测试以确定细菌活力降低.
主要成果:
- 合成的二氧化微粒具有高BAC负荷 (0.56g/gSiO2),高表面积 (1500 m2/g) 和18 Å孔径.
- 在没有表面修改的情况下,证明了对pH的响应,控制BAC的释放.
- 在酸性和中性pH下,Korsmeyer-Peppas模型分析显示出不同的释放机制.
- 观察到Staphylococcus aureus和Salmonella enterica活力的显著时间依赖性降低.
结论:
- 新型中等孔性微粒是有效的DDS用于pH响应释放的BAC.
- 这些材料具有强大的抗菌活性,对抗阳性和阴性细菌.
- 这些发现支持BAC在制药和食品应用中作为消毒剂的广泛使用.
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