十二步非对称合成 (-) - 诺杜利斯酸C
Nicole A Godfrey1, Devon J Schatz1, Sergey V Pronin1
1Department of Chemistry , University of California, Irvine , Irvine , California 92697-2025 , United States.
Journal of the American Chemical Society
|September 29, 2018
概括
这项研究提供了一个简洁的,对 (-) - 诺杜利斯酸C的选择性合成.高效的12步路径使用关键的多环化和合组合用于印罗特类标.
科学领域:
- 有机化学
- 自然产品合成
背景情况:
- (-) - 诺杜利斯酸C是一种具有潜在生物活性的复杂内类化合物.
- 有效的合成途径对于获得这些复杂的自然产品至关重要.
研究的目的:
- 开发一个短和enantioselective合成的 (-) -nodulisporic酸C.
- 展示复杂分子构建的新合成方法的实用性.
主要方法:
- 使用二选择性多环化进行的对抗选择性合成.
- 一个具有挑战性的内部分的融合组合.
- 使用商业可用的原材料进行简化.
主要成果:
- 通过12步合成 (-) - 诺杜利斯酸C.
- 在关键的多环化步骤中表现出高的二选择性.
- 已经成功构建了复杂的基核和基碎片.
结论:
- 开发的合成途径是高效和对抗选择性的.
- 该方法适用于合成其他复杂的内类药物.
- 这项工作为获取 (-) - 节酸C提供了有价值的途径.
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