磁共振成像纳米探针的生物相容性通过可转换的氧化物纳米线圈得到改善
Dan Luo1, Shengjie Cui2, Yan Liu2
1State Key Laboratory of Heavy Oil Processing, Institute of New Energy, Beijing Key Laboratory of Biogas Upgrading Utilization , China University of Petroleum Beijing , Beijing 102249 , China.
Journal of the American Chemical Society
|October 3, 2018
概括
超薄的氧化物纳米线圈为生物医学应用提供了更好的生物相容性. 它们独特的结构减少了蛋白质的粘附和细胞吸收,提高了纳米药物开发的安全性.
科学领域:
- 材料科学
- 纳米技术
- 生物医学工程
背景情况:
- 纳米科学在了解生物医学使用纳米材料的毒性方面面临挑战.
- 蛋白质吸附和细胞吸收是纳米探测器的主要毒性来源.
研究的目的:
- 制造和描述超薄的氧化物纳米线圈.
- 研究这些纳米线圈的生物相容性和成像特性.
主要方法:
- 制造具有低Young模量的超薄氧化物 (Gd2O3) 纳米线圈.
- 蛋白质吸附和细胞吸收的评估.
- 评估T1磁共振成像对比度和体内生物成像.
主要成果:
- 在溶液中,Gd2O3纳米线圈表现出由于其低模的可变性.
- 纳米线圈结构诱导了固体排斥,减少了蛋白质吸附和细胞吸收.
- 通过大量暴露表面的加多原子,获得了增强的T1MRI对比度.
- 在体内MRI生物成像显示血液循环寿命延长.
结论:
- 可转换的Gd2O3纳米线圈通过最大限度地减少蛋白质吸附和细胞吸收来提高生物相容性.
- 这些纳米线圈为体内应用提供了增强的MRI成像对比度和延长的循环.
- 设计方法为开发更安全的纳米生物药物提供了新的视角.
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