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Updated: Feb 4, 2026

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编者纠正:NORAD lncRNA组装了一个对基因组稳定性至关重要的拓酶复合体

Mathias Munschauer1, Celina T Nguyen2, Klara Sirokman2

  • 1Broad Institute of MIT and Harvard, Cambridge, MA, USA. mathias@broadinstitute.org.

Nature
|October 4, 2018
PubMed
概括

这项研究涉及在一封已发表的信中对审查员的信息进行了修正. 更新确保了科学记录的准确性,以提高研究完整性.

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DNA Topoisomerases02:02

DNA Topoisomerases

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lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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