阿斯加德古生物的基因组编码了调节动蛋白的蛋白质
Caner Akıl1,2, Robert C Robinson3,4,5
1Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore, Singapore.
Nature
|October 5, 2018
概括
阿斯加德古生物具有功能性的动因细胞骨,由它们的蛋白质表示. 这一发现为真核细胞的早期进化及其复杂的细胞机械提供了洞察力.
科学领域:
- 细胞生物学
- 进化生物学
- 微生物学
背景情况:
- 细胞的起源仍然是一个重要的科学问题.
- 转基因组学表明了古生物和真核生物之间的联系,阿斯加德古生物显示了真核生物的基因同类.
- 这些考古同类的功能相关性尚未完全理解.
研究的目的:
- 调查阿斯加德古生物中的蛋白质的存在和功能.
- 确定阿斯加德古生物是否具有受调的行为细胞骨架.
- 了解行为细胞骨架组件的进化历史.
主要方法:
- 来自阿斯加德古生物 (Loki,Odin,Heimdall) 的蛋白质的生物化学分析.
- 与哺乳动物和子的行为相互作用研究.
- 在古老的脂蛋白和脂蛋白的存在下进行的动素聚合和核化试验.
主要成果:
- 阿斯加德古生物编码与动蛋白相互作用的功能性蛋白质.
- 这些古老的蛋白质调节了actin的聚合和核化,这表明了原始的actin系统.
- 阿斯加德蛋白与聚烯基基因不相互作用,这表明这种相互作用在真核生物中是以后发生的.
结论:
- 阿斯加德古生物具有调节的行为细胞骨架,这是一个关键的真核生物特征.
- 这一发现支持了古细胞中真核细胞起源的假设.
- 古代的行为系统可能是与膜相关的和原始的,早于复杂的真核细胞骨功能.
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