相关实验视频
Updated: Feb 4, 2026

13:48
Design and Construction of an Urban Runoff Research Facility
Published on: August 8, 2014
13.6K
暴露隐藏在动物设施中的病毒
1Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Cell
|October 6, 2018
概括
一种新发现的病毒,小鼠病病毒 (MKPV),导致实验室小鼠常见的病. 这一发现为管间纤维化提供了新的见解,并有助于开发更好的诊断工具.
科学领域:
- 兽医病理学
- 病毒学
- 肝脏病学
背景情况:
- 一种导致实验室小鼠自发性病的病早已被发现.
- 在小鼠模型中这种常见疾病的病因仍未确定.
- 这种脏病与了解哺乳动物的管间纤维化有关.
研究的目的:
- 在实验室小鼠中识别自发性病的致病因.
- 描述新发现的病毒及其流行情况.
- 探索对诊断和理解纤维化的影响.
主要方法:
- 在受影响的小鼠中检测和测序病毒原体.
- 组织病理分析.
- 在不同的小鼠群体中进行流行评估.
主要成果:
- 一种新型的帕维病毒,称为小鼠帕维病毒 (MKPV),被确定为病的原因.
- 在实验室小鼠群体中发现MKPV的广泛存在.
- 目前的诊断方法未能检测到MKPV,
结论:
- 鉴定MKPV为老鼠的长期病提供了明确的原因.
- 了解MKPV的作用为研究管间纤维化开辟了新的途径.
- 开发特定的MKPV诊断试验是有必要的,以改善小鼠群的健康和研究准确性.
相关概念视频
What are Viruses?
128.2K
Overview
128.2K
Animal Mitochondrial Genetics
9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K
Tonicity in Animals
124.5K
The tonicity of a solution determines if a cell gains or loses water in that solution. The tonicity depends on the permeability of the cell membrane for different solutes and the concentration of nonpenetrating solutes in the solution within and outside of the cell. If a semipermeable membrane hinders the passage of some solutes but allows water to follow its concentration gradient, water moves from the side with low osmolarity (i.e., less solute) to the side with higher osmolarity (i.e.,...
124.5K
Tonicity in Animals
5.3K
Tonicity describes the amount of solute in a solution. The measure of the tonicity of a solution, or the total amount of solutes dissolved in a specific amount of solution, is called its osmolarity. Three terms—hypotonic, isotonic, and hypertonic—are used to relate the osmolarity of a cell to the osmolarity of the extracellular fluid that contains the cells. In a hypotonic solution, such as tap water, the extracellular fluid has a lower concentration of solutes than the fluid inside...
5.3K
Introduction to Virus
1.7K
Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
1.7K
Viruses of Archaea
509
Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
509

