证据表明RNA病毒推动了尼安德特人与现代人类之间的自适应性进攻
David Enard1, Dmitri A Petrov2
1Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA.
Cell
|October 6, 2018
概括
在现代人类中保留的尼安德特人DNA片段经常与病毒相互作用. 这些进化序列,特别是影响欧洲人RNA病毒相互作用的序列,揭示了适应性益处和古老的流行洞察力.
科学领域:
- 古病毒学
- 人类进化遗传学
- 古代DNA分析
背景情况:
- 现代人类与尼安德特人交配, 引入了尼安德特人的DNA片段.
- 大多数进化DNA是通过选择去除的,但保留的细分的适应性作用是不太了解的.
研究的目的:
- 调查杂交是否促进了对病毒耐药性的适应性等位基因交换.
- 确定保留的尼安德特人DNA片段是否富含病毒相互作用蛋白 (VIP).
主要方法:
- 对现代人类基因组内进化的DNA段的分析.
- 对病毒蛋白相互作用进行丰富的尼安德特人祖先细分的鉴定.
- 专注于欧洲人群中与RNA病毒相互作用的VIP.
主要成果:
- 在现代人类中长且频繁的尼安德特人DNA片段被丰富为VIP.
- 与RNA病毒相互作用的VIP在欧洲人中更为普遍.
- 保留的尼安德特人DNA提供了古代流行病暴露的标记.
结论:
- 尼安德特人与现代人类的杂交导致了病毒抗性基因的自适应性内进.
- 保留的尼安德特人DNA片段提供了对古代病毒威胁的进化反应的见解.
- 进化序列的分析可以作为研究过去的流行病的代理.
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