由新陈代谢状态控制的内皮细胞到脂肪细胞外囊轴
Clair Crewe1, Nolwenn Joffin1, Joseph M Rutkowski1
1Touchstone Diabetes Center, Department of Internal Medicine, the University of Texas Southwestern Medical Center, Dallas, TX, USA.
Cell
|October 9, 2018
概括
脂肪组织细胞通过细胞外囊泡 (EV) 进行通信. 内皮细胞将含有caveolin 1 (cav1) 的EV转移到脂肪细胞中,然后进行互换,揭示出一种新的细胞间信号通路.
科学领域:
- 细胞生物学
- 代谢过程
- 生理学
背景情况:
- 细胞外囊泡 (EVs) 调解细胞间的通信.
- 洞穴蛋白1 (cav1) 在细胞过程中起作用.
- 脂肪组织 (AT) 存在复杂的细胞相互作用.
研究的目的:
- 研究脂肪细胞和脂肪组织内皮细胞 (ECs) 之间的EV介导信号.
- 了解cav1在细胞间交流中的作用.
- 探索这些信号的生理调节.
主要方法:
- 用于研究细胞间 EV 转移的新型小鼠模型的生成.
- 在体内分析脂肪细胞和EC之间的EV交换.
- 评估cav1蛋白质含量和EV含量
主要成果:
- 脂肪细胞和EC在体内进行双向的EV交换.
- ECs将含有cav1的EV转移到脂肪细胞;脂肪细胞与EV互惠.
- 电流器促进了等离子体成分的转移,并调节了信号通路.
- 这种EV传播受营养状况 (禁食/再食) 和肥胖影响.
结论:
- 脂肪细胞和脂肪组织中的EC之间存在通过EV进行细胞间通信的新机制.
- 这一途径涉及cav1和其他生物分子的转移,影响细胞信号和营养物质的交换.
- 脂肪组织中的EV介导信号由生理状态动态调节,影响组织功能和全身营养反应.
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