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在14-3-3蛋白相互作用中的多价值的热力学模型

Loes M Stevers1, Pim J de Vink1, Christian Ottmann1

  • 1Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems , Technische Universiteit Eindhoven , P.O. Box 513, Eindhoven 5600 MB , The Netherlands.

Journal of the American Chemical Society
|October 10, 2018
PubMed
概括

我们开发了一种多价值蛋白与蛋白相互作用的热力学模型, 揭示了多个结合点如何影响结合亲和力. 这项工作为复杂疾病的药物发现提供了PPI稳定性的见解.

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