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通过信号干扰通过益生菌消除病原体

Pipat Piewngam1,2, Yue Zheng1, Thuan H Nguyen1

  • 1Pathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Nature
|October 12, 2018
PubMed
概括

益生菌细菌通过脂消除金黄色葡萄球菌通过阻断其定量感应. 这种益生菌机制减少了病原体的殖民化,并为脱殖和抗击感染提供了新的策略.

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科学领域:

  • 微生物学
  • 人类健康
  • 益生菌营养

背景情况:

  • 据说益生菌可以通过减少病原体殖民来改善人类健康.
  • 这些健康益处背后的确切机制尚未完全理解.
  • 降低病原体易感性是传染病研究的一个关键领域.

研究的目的:

  • 研究益生菌减少病原体殖民的分子机制.
  • 为了确定益生菌Bacillus在预防黄金葡萄球菌殖民的有效性.
  • 探索抗击金黄色葡萄球菌感染的新方法.

主要方法:

  • 泰国农村居民消费益生菌.
  • 细菌脂的分析,特别是.
  • 对黄金葡萄球菌 (Staphylococcus aureus) 的检测途径进行调查.

主要成果:

  • 消费益生菌完全阻止了黄金葡萄球菌的殖民化.
  • 鉴定出素是消灭黄金菌的活性化合物.
  • 素可以抑制S. aureus的群体感知,这是细菌的沟通系统.
  • 这种机制通过阻断病原体信号来证明益生菌的干扰.

结论:

  • 益生菌营养,特别是细菌的消费,有效地减少了黄金葡萄球菌的殖民.
  • 素通过破坏黄金菌的定数感应在益生菌的有效性中起着至关重要的作用.
  • 阻止病原体信号系统为脱殖和感染控制提供了一个有前途的途径.
  • 这项研究提供了益生菌降低传染病风险的分子基础.