具有不连接的法医和生物医学位置的亲属的统计检测
Jaehee Kim1, Michael D Edge2, Bridget F B Algee-Hewitt1
1Department of Biology, Stanford University, Stanford, CA 94305, USA.
Cell
|October 16, 2018
概括
法医遗传学现在可以使用非重叠的DNA标记来识别亲属. 这种链接不平衡方法将SNP配置文件与微卫星数据库连接起来,增强家族搜索并揭示隐私风险.
科学领域:
- 法医遗传学
- 人口遗传学
- 生物信息学
背景情况:
- 在法医遗传学中的家族搜索使用DNA档案来找到数据库进入者的亲属.
- 目前的方法通常需要查询和数据库配置文件之间重叠的遗传标记.
- 探索新的方法对于扩大法医DNA数据库的实用性至关重要.
研究的目的:
- 在基因标记不重叠的情况下,研究使用链接不平衡来识别相关个体的潜力.
- 评估在家族搜索中交叉引用不同类型的遗传数据 (微卫星和SNP) 的可行性.
- 在不同的基因数据库中评估家族搜索的隐私影响.
主要方法:
- 利用具有微卫星和全基因组SNP标记的个体的基因型数据.
- 应用链接不平衡分析以识别使用非重叠标记集的相关对 (父母-后代,兄弟姐妹).
- 使用SNP资料与微卫星数据库进行模拟家族搜索,反之亦然.
主要成果:
- 通过非重叠标记数据成功识别了大约30-32%的父子对和35-36%的兄弟姐妹对.
- 当查询和数据库配置文件使用不同的标记类型 (SNP与微卫星) 时,证明了进行家族搜索的潜力.
- 突出了个人及其亲属在缺乏共同遗传标记的数据库中搜索时存在的重大隐私风险.
结论:
- 在法医遗传学中,链接不平衡提供了一个不重叠的遗传标志物用于家族搜索的可行方法.
- 这种方法提高了利用多种法医DNA数据库进行亲属识别的能力.
- 跨数据库的家庭搜索,即使没有共享标记,也需要仔细考虑所有参与者的隐私问题.
相关概念视频
Statistical Significance
21.8K
Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
21.8K
Types of Errors: Detection and Minimization
11.4K
Error is the deviation of the obtained result from the true, expected value or the estimated central value. Errors are expressed in absolute or relative terms.
Absolute error in a measurement is the numerical difference from the true or central value. Relative error is the ratio between absolute error and the true or central value, expressed as a percentage.
Errors can be classified by source, magnitude, and sign. There are three types of errors: systematic, random, and gross.
Systematic or...
Absolute error in a measurement is the numerical difference from the true or central value. Relative error is the ratio between absolute error and the true or central value, expressed as a percentage.
Errors can be classified by source, magnitude, and sign. There are three types of errors: systematic, random, and gross.
Systematic or...
11.4K
Probability in Statistics
23.4K
Probability is the likelihood of an event occurring. The term event is defined as a collection of results of a procedure. An event is a simple event when an outcome cannot be divided into simpler parts.
An example of a simple event is a coin toss. The result of a coin toss is either a head or a tail. Here, head and tail are two simple events. These two simple events make up the sample space. Further, the probability of an event occurring falls within the range of 0 to 1. The probability of an...
An example of a simple event is a coin toss. The result of a coin toss is either a head or a tail. Here, head and tail are two simple events. These two simple events make up the sample space. Further, the probability of an event occurring falls within the range of 0 to 1. The probability of an...
23.4K
Introduction to Statistics
63.9K
The science of statistics involves collecting, analyzing, interpreting, and presenting data. The method of collecting, organizing, and summarizing data is called descriptive statistics. The systematic method of drawing inferences from the sample data and predicting unknown characteristics of a population is called inferential statistics.
In statistics, the collection of individuals or objects under study is called population. The idea of sampling is to select a portion of the larger population...
In statistics, the collection of individuals or objects under study is called population. The idea of sampling is to select a portion of the larger population...
63.9K
Root Loci for Positive-Feedback Systems
350
The Hartley oscillator is a positive feedback system that sustains oscillations by feeding the output back to the input in phase, thereby reinforcing the signal. Positive feedback systems can be viewed as negative feedback systems with inverted feedback signals. In these systems, the root locus encompasses all points on the s-plane where the angle of the system transfer function equals 360 degrees.
The construction rules for the root locus in positive feedback systems are similar to those in...
The construction rules for the root locus in positive feedback systems are similar to those in...
350
Statistical Analysis: Overview
16.6K
When we take repeated measurements on the same or replicated samples, we will observe inconsistencies in the magnitude. These inconsistencies are called errors. To categorize and characterize these results and their errors, the researcher can use statistical analysis to determine the quality of the measurements and/or suitability of the methods.
One of the most commonly used statistical quantifiers is the mean, which is the ratio between the sum of the numerical values of all results and the...
One of the most commonly used statistical quantifiers is the mean, which is the ratio between the sum of the numerical values of all results and the...
16.6K


