基于暂时涂层的延迟传感器激活:复杂生物流体中的生物污染保护
Víctor Ruiz-Valdepeñas Montiel1,2, Juliane R Sempionatto1, Berta Esteban-Fernández de Ávila1
1Department of Nanoengineering , University of California, San Diego , La Jolla , California 92093 , United States.
Journal of the American Chemical Society
|October 19, 2018
概括
可编程的短暂涂层可以延迟传感器的激活, 克服生物污染,
科学领域:
- 材料科学
- 生物医学工程
- 传感器技术
背景情况:
- 生物污染显著限制了复杂生物流体中的电化学生物传感器的性能和寿命.
- 现有的传感器技术由于生物污染和需要频繁更新表面而难以持续监测.
- 为了克服这些局限性,可以延迟传感表面的启动.
研究的目的:
- 开发可编程多电极传感器阵列的过渡性聚合物涂层.
- 研究这些涂料的抗生物污染特性和可调节的顺序执行能力.
- 通过开发的延迟传感器系统,证明未经处理的生物流体中直接监测葡萄糖的可行性.
主要方法:
- 具有定制密度和厚度的过渡性聚合物涂层的制造.
- 涂层溶解速率的表征和单个传感电极的顺序执行.
- 在未经处理的血液和唾液样本中应用延迟传感系统进行直接血糖监测.
主要成果:
- 暂时的涂层使得可编程的,延迟的新传感器表面暴露.
- 控制的涂层特性允许可调节的传感电极的顺序激活.
- 在长时间内实现未经处理的血液和唾液中的直接血糖监测,减少了生物污染.
结论:
- 过渡性聚合物涂层为延迟传感器启动和抗生物污染提供了可行的策略.
- 开发的延迟传感器曝光概念显示出在复杂的生物流体中持续运行的重大前景.
- 这项技术可以在诊断和医疗保健中实现长期的实地监测应用.
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