神经系统区域化包括神经区分之前的轴向分配
Vicki Metzis1, Sebastian Steinhauser1, Edvinas Pakanavicius1
1The Francis Crick Institute, London NW1 1AT, UK.
Cell
|October 23, 2018
概括
脊椎动物的神经诱导涉及初级区域化,在细胞成为神经之前,它们会致力于前部或后部命运. 这挑战了现有的中枢神经系统发育和神经元生成模型.
科学领域:
- 发育生物学
- 神经科学
- 基因组学
背景情况:
- 神经诱导建立了脊椎动物的中枢神经系统 (CNS).
- 传统模型假定前部神经认同,其次是后部命运的尾部.
- 了解特定区域的神经命运获取至关重要.
研究的目的:
- 在神经诱导过程中研究细胞命运的时间动态.
- 挑战和完善神经诱导和中枢神经系统模式的现有模式.
- 阐明脑和脊髓神经元的产生机制.
主要方法:
- 染色体可访问性测试用于绘制细胞状态.
- 遗传和生化方面的干扰.
- 对全基因组染色体重塑事件的分析.
主要成果:
- 确定了神经诱导前染色体重塑的关键发育窗口.
- 证明细胞在神经认同之前承诺区域认同 (前/后).
- 揭示了"初级区域化"过程,将细胞分配到中枢神经系统区域.
结论:
- 这些发现需要对当前的神经诱导模型进行修订.
- 支持脊椎动物中枢神经系统发育中的初级区域化概念.
- 提供关于脊椎动物中枢神经系统的进化起源的见解.
相关概念视频
What is a Nervous System?
104.8K
Overview
104.8K
The Parasympathetic Nervous System
115.5K
Overview
115.5K
The Sympathetic Nervous System
103.6K
Overview
103.6K
Neural Regulation
43.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.4K
Axial and Appendicular Muscles
2.7K
Skeletal muscles, the key players in our body's movement, can be classified into two groups based on their location and function: axial muscles and appendicular muscles. These classifications reflect the primary roles the muscles play in the body's structure and movement.
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
2.7K
Overview of the Axial Skeleton
9.3K
The skeleton is subdivided into two major divisions—the axial skeleton and the appendicular skeleton. The axial skeleton forms the vertical, central axis of the body. It includes all of the bones of the head, neck, chest, and back. It protects the brain, spinal cord, heart, and lungs. It also serves as the attachment site for muscles that move the head, neck, and back and for muscles that act across the shoulder and hip joints to move their corresponding limbs.
The axial skeleton of the...
The axial skeleton of the...
9.3K


