在Si-P,Si-S,Si-N和C-C键中插入基的新阻胺基
Milad Mesgar1, Justin Nguyen-Le1, Olafs Daugulis1
1Department of Chemistry , University of Houston , Houston , Texas 77204-5003 , United States.
Journal of the American Chemical Society
|October 24, 2018
概括
一种新的阻碍胺基能够有效地插入到各种键,包括Si-P,Si-S,Si-N和C-C. 这种方法为复杂的分子提供了多功能的一步合成,
科学领域:
- 有机化学
- 有机金属化学
背景情况:
- 在合成复杂的有机分子方面,
- 开发新的试剂来控制的反应性对于合成进步至关重要.
研究的目的:
- 引入一种新的阻碍胺基,二胺 (LDAM).
- 为了证明LDAM在促进aryne插入反应中的实用性.
- 开发一种单步合成的炭.
主要方法:
- 酸是由酸和化物生成的.
- 由此产生的氨基酸与化,硫化物和氨基进行了插入反应.
- 使用烯化物和酸实现了一步合成.
主要成果:
- 使用LDAM实现了对Si-P,Si-S,Si-N和C-C键的有效插入.
- 与四甲基化物 (LiTMP) 相比,LDAM基提供了更高的产量.
- 包括,,和在内的各种功能组与反应条件相容.
结论:
- LDAM 是一种高效的基因,用于 aryne 插入反应.
- LDAM的体积最大限度地减少了与基的副作用反应,使其成为限制试剂.
- 这种方法为构建多样化的有机结构提供了强大的工具.
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