对缺血性心脏病的重新评估
Juan-Carlos Kaski1, Filippo Crea2, Bernard J Gersh3
1Molecular and Clinical Sciences Research Institute, St George's, University of London, United Kingdom (J.-C.K).
Circulation
|October 26, 2018
概括
冠状动脉微血管功能障碍是胸痛的主要原因,影响有或没有阻塞性冠状动脉疾病的患者. 了解和治疗这种被称为微血管性心痛的疾病对于改善患者的治疗结果至关重要.
科学领域:
- 心脏病学
- 血管生物学
- 缺血性心脏病
背景情况:
- 冠状动脉微血管功能障碍 (CMD) 越来越多地被认为是胸痛的重要因素.
- 通过结构和功能机制影响冠状动脉功能,导致心肌缺血.
研究的目的:
- 讨论CMD在缺血性心脏病中的致病作用.
- 概述微血管性心痛的临床特征.
- 探索CMD的诊断和治疗策略.
主要方法:
- 对冠状动脉微血管功能障碍和微血管性心痛的当前文献的综述.
- 分析病原机制,包括异常扩张反应,和外血管力.
- 对冠状动脉流量储备减少和微血管的诊断工具的讨论.
主要成果:
- 在患有或没有阻塞性冠状动脉疾病的患者中,CMD有助于心肌缺血,包括心脏移植或心脏再循环后心痛患者.
- 微血管性心痛的特征是心痛症状和心肌缺血,通常是冠状动脉流量减少或.
- 这种疾病影响生活质量,预后和医疗费用,在临床实践中越来越多地被发现.
结论:
- 冠状动脉疾病是缺血性心脏病和微血管性心痛的根本原因.
- 对CMD的有效治疗仍然是一个重大的临床挑战.
- 需要进一步研究诊断和治疗策略.
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