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现代化心脏节律障碍药物分类

Ming Lei^1,2, Lin Wu^3,2, Derek A Terrar¹

¹Department of Pharmacology, University of Oxford, United Kingdom (M.L., D.A.T.).

|October 26, 2018

概括

一个修订的抗节律药物分类扩展了原来的沃恩·威廉姆斯系统. 这一更新的框架包含了新的目标,并有助于理解和治疗心律失常.

科学领域:

心血管药理学
心脏电生理学
药物发现

背景情况:

迈尔斯·沃恩·威廉姆斯 (Miles Vaughan Williams) 开发了一种基本的抗节律药物分类.
这种分类对抗心律失常疗法的临床使用和理解至关重要.
最近的发现需要更新抗失常药物分类的框架.

研究的目的:

开发一种扩展和实用的抗心律障碍药物分类.
纳入最近的分子目标和细胞电生理学的发现.
为分类现有和新型心律失常药物提供现代化的框架.

主要方法:

在 sarcolemmal,sarcoplasmic reticular和细胞质生物分子中发现的调查影响.
将药物目标跟踪到细胞电生理效应.
根据新的发展,对现有的沃恩·威廉姆斯I-IV类进行分类,并为额外的目标引入新类.

主要成果:

保留了沃恩·威廉姆斯I-IV类,并对Na+电流成分,自主信号,K+通道亚种和Ca2+平衡进行了分类.
引入了针对目标的新类,包括自动性通道,机械敏感离子通道,连接素和重塑相关分子.
修订后的分类包括多种药物标,作用和不良反应,包括潜在的心律失常.

结论:

现代化的分类保留了原来的沃恩·威廉姆斯框架的简单性.
更新后的系统有助于对心律失常的理解和临床治疗.
这一修订后的分类有助于未来的抗心律失常药物研究和应用.

关键词:

抗心律失常剂心律不整,心脏病恒常状态离子通道

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