瘤微环境响应超小纳米药物生成器,增强瘤传递和透
Pengfei Zhang1, Junqing Wang1, Hu Chen1
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health , Xiamen University , Xiamen 361102 , China.
Journal of the American Chemical Society
|October 26, 2018
概括
瘤微环境触发的超小纳米药物生成 (TMIUSNG) 增强了药物输送. 新型金属有机纳米药物复合物 (MONCs) 释放强大的超小纳米颗粒,改善瘤的透和有效性.
科学领域:
- 生物医学工程
- 纳米技术
- 材料科学
背景情况:
- 药物输送系统面临着透性和稳定性等挑战.
- 瘤微环境 (TME) 为向药物释放提供独特的刺激.
- 超微型纳米药物生成是一种克服交付障碍的新策略.
研究的目的:
- 开发一种瘤微环境诱导的超小纳米药物生成 (TMIUSNG) 的新战略.
- 合成和描述用于增强癌症治疗的金属有机纳米药物复合物 (MONC).
- 研究TME中MONC组装,拆卸和药物释放的机制.
主要方法:
- 超分子组合的sinoporphyrin, doxorubicin,和铁离子形成MONCs.
- MONCs的特征,包括大小,形态和药物负载效率 (DLE).
- 评估活性氧物种 (ROS) 的产生和体外/体内治疗疗效.
主要成果:
- 与免费光敏感剂相比,MONCs表现出增强的ROS生成 (3倍).
- 作为对酸性TME的反应,MONC有效地产生了超小的纳米药物 (5-10纳米).
- 这项TMIUSNG策略显著改善了瘤内透性和治疗结果.
结论:
- 使用MONC开发的TMIUSNG战略为克服药物输送障碍提供了一个有希望的方法.
- 这项概念验证研究为设计无载体纳米器件奠定了基础.
- 这些发现突显了结合治疗剂和金属离子治疗晚期癌症的潜力.
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