自组装纳米结构调节构成同位素的H2S释放
Yin Wang1, Kuljeet Kaur1, Samantha J Scannelli1
1Department of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute , Virginia Tech , Blacksburg , Virginia 24061 , United States.
Journal of the American Chemical Society
|October 30, 2018
概括
研究人员开发了可以自组成不同纳米结构的酸 (H2S) 供体结合物 (PHDC). 在H2S释放生物材料中,纳米卷PHDC显示出优异的多克索鲁比辛心脏毒性减轻作用.
科学领域:
- 生物材料科学
- 超分子化学
- 医学化学
背景情况:
- 硫化 (H2S) 是一种具有治疗潜力的生物信号气体.
- 开发可控的H2S输送系统对于治疗应用至关重要.
- 的自组合提供了一个创建功能纳米材料的平台.
研究的目的:
- 合成和表征硫化供体结合物 (PHDC).
- 研究PHDC的自我组装行为和H2S释放动力学.
- 评估PHDCs在减轻多克索鲁比辛诱导的心脏毒性的疗效.
主要方法:
- 用S-aroylthiooximes (SATOs) 功能化的三种构成异构PHDC含有谷氨酸和氨酸残留物的合成.
- 在水溶液中将PHDC自组装成不同的形态 (纳米丝带和纳米线圈) 的特征.
- 评估H2S释放率及其对形态和SATO分解的依赖性.
- 通过不同的PHDC形态对多克索鲁比辛心脏毒性减轻的体外评估.
主要成果:
- 自组装成不同的纳米结构的PHDC:两个纳米带和一个纳米线圈.
- 随着形态的变化,H2S的释放速度有所不同;纳米线圈表现出复杂的释放动力学.
- 形成纳米线圈的PHDC显著减轻了多克苏的心脏毒性,其性能优于纳米带异构体和传统的H2S供体.
结论:
- 可以设计PHDC自组装成各种纳米结构,并可调节H2S释放.
- 形态在PHDC的H2S释放特征和治疗效果上起着至关重要的作用.
- 这项研究提出了开发具有潜在治疗应用的先进H2S释放生物材料的新策略.
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