左心房附属体在心房中所起的血栓形成和节律失常作用
Luigi Di Biase1, Andrea Natale1, Jorge Romero1
1Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Circulation
|October 30, 2018
概括
左心房附属体 (LAA) 在心房动中起着关键作用,有助于血栓形成和心律失常. 针对LAA的治疗方法,如电隔离或绑定,有望对这些疾病进行管理.
科学领域:
- 心脏病学
- 电生理学
- 血管生物学
背景情况:
- 左心房附属体 (LAA) 在心房的病理生理学中发挥关键作用,特别是在血栓形成和心律失常中.
- 了解LAA解剖学和生理学对于开发有效的AF治疗至关重要.
- LAA是非膜性肌痛的主要血栓来源,其形态影响了血栓栓塞的风险.
研究的目的:
- 审查LAA在心房的解剖学,生理学和临床意义.
- 讨论LAA干预的作用,包括电隔离和绑定,在管理AF和相关风险.
- 突出LAA电隔离的安全性和有效性及其对抗凝血策略的影响.
主要方法:
- 关于LAA解剖学,生理学和AF中的作用的文献综述.
- 对LAA电隔离和绑定结果的临床数据分析.
- 评估与LAA干预相关的程序风险和益处.
主要成果:
- LAA的形态可以影响血栓形成,并有助于血栓栓塞事件的风险分层.
- 在AF的导管切除过程中可以实现LAA的电隔离,但晚期重新连接很常见.
- LAA结合可能会调节氨酸-氨酸-氨酸系统,影响血压控制.
结论:
- 如果患者坚持终身抗凝治疗,LAA电隔离是一种安全的AF治疗方法.
- 在LAA手术中需要特别注意,以避免心肌穿孔或神经/动脉损伤等并发症.
- 针对LAA提供了一个有前途的治疗策略,以改善心房的患者的治疗结果.
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