下肢表面血栓炎的治疗方法
Marcello Di Nisio1, Iris Wichers2, Saskia Middeldorp1
1Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, the Netherlands.
JAMA
|November 2, 2018
概括
在表面性血栓炎 (ST) 患者中,芬达帕努克斯显著降低了症状性静脉血栓事件 (VTE),但没有增加出血. 低分子量肝素和NSAIDs可能有助于预防ST延伸,但VTE数据不确定.
科学领域:
- 血管医学
- 药理学
- 临床血栓形成
背景情况:
- 表面血栓炎 (ST) 是一种涉及表面静脉炎症和凝血的疾病.
- 静脉血栓事件 (VTE) 是ST的一个潜在并发症.
- 需要澄清ST的最佳治疗策略, 以尽量减少VTE的风险.
研究的目的:
- 评估下肢表面血栓炎的治疗方法.
- 为了比较各种ST治疗与安慰剂相关的静脉血栓事件 (VTE) 的发生率.
主要方法:
- 随机对照试验的系统审查和元分析,将ST治疗与安慰剂进行比较.
- 包括评估芬达巴努克斯,低分子量肝素 (LMWH),非类固醇抗炎药物 (NSAIDs) 和口服里瓦洛克萨班的研究.
主要成果:
- 与安慰剂相比,芬达巴林克斯 (每日2.5毫克皮下注射45天) 与较少的症状性静脉动脉事件有关,而严重出血的发生没有显著增加.
- 与安慰剂相比,低分子量肝素 (LMWH) 和非类固醇抗炎药物 (NSAID) 的ST延长或复发率较低.
- 关于LMWH和NSAID对症状性VTE发生率的影响的证据尚不确定.
- 需要进一步研究其在ST治疗中的有效性和安全性.
结论:
- 作为一种有效的治疗方法,芬达帕努克斯可以减少表面性血栓炎的VTE.
- 对于局部ST进展来说,LMWH和NSAID可能有益,但需要更多的数据来评估VTE风险.
- 对口服抗凝剂如里瓦洛克萨班在治疗ST方面进行进一步研究是有必要的.
相关概念视频
Absolute and Local Extreme Values
74
The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...
74
Open Angle Glaucoma: Treatment
997
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
997
Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Parkinson's Disease: Treatment
1.2K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.2K
Alzheimer's Disease: Treatment
952
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
952
Anticholinesterase Agents: Poisoning and Treatment
1.6K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.6K


