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用于分子成像和光动力学治疗的可激活探头的电色材料工程
Luyan Wu1, Yidan Sun1, Keisuke Sugimoto2
1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering , Nanjing University , Nanjing 210023 , China.
Journal of the American Chemical Society
|November 3, 2018
概括
研究人员设计了一种电色材料 (EM) 作为对硫化 (H2S) 敏感的探针,用于体内成像和治疗. 这种可激活H2S的光探测器可以实时检测和光动力治疗小鼠的瘤.
科学领域:
- 材料科学
- 生物医学工程
- 有机化学
背景情况:
- 电色材料 (EMs) 是可以切换颜色的材料,具有作为刺激反应生物材料的未开发潜力.
- 在体内使用EMS监测和控制生物过程仍然是一个重大挑战.
研究的目的:
- 设计一种以π电子结构为基础的有机电磁体,作为对硫化 (H2S) 敏感的染色体.
- 开发可激活H2S的光探针 (12+-SNP) 用于体内检测H2S和光动力疗法 (PDT).
主要方法:
- 设计了一种具有强吸收 (500-850 nm) 和光灭特性的新型电磁波 (12+).
- 构建了12+半导体聚合物纳米粒子 (12+-SNP) 用于H2S检测.
- 使用H2S调节12+为二烯2以恢复成像的光.
- 开发了一种针对瘤的H2S可激活的近红外光敏感剂.
主要成果:
- 在12+-SNP中有效灭光,在H2S暴露时恢复光.
- 在小鼠中实现肝脏和瘤H2S的非侵入性实时成像.
- 使用工程光敏感剂对小鼠的H2S相关瘤进行有效PDT.
结论:
- 工程 EM 12+ 作为 H2S 响应分子成像和向 PDT 的多功能平台.
- 这种方法有望开发用于检测和调节体内生物过程的新型电磁体.
- 这项研究强调了EM在先进的生物医学应用中的潜力.
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