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Updated: Feb 3, 2026

Zinc-finger Nuclease Enhanced Gene Targeting in Human Embryonic Stem Cells
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通过CRBN定义人类的C2H2指降解基因

Quinlan L Sievers1,2, Georg Petzold3, Richard D Bunker3

  • 1Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Science (New York, N.Y.)
|November 3, 2018
PubMed
概括

塔利多米德类型的目标是Cys2-His2指蛋白,由CRL4CRBN E3无素连接酶降解. 这项研究发现了新的指降解剂,扩大了以前认为无法治疗的治疗点.

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