美国移民使人类肠道微生物群向西方化
Pajau Vangay1, Abigail J Johnson2, Tonya L Ward2
1Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN 55455, USA.
Cell
|November 3, 2018
概括
美国移民迅速减少了肠道微生物群的多样性和功能,使本地微生物被美国相关的菌株所取代. 这些变化随着时间的推移,肥胖和几代人而变得更糟.
科学领域:
- 人类健康
- 微生物组研究
- 移民研究
背景情况:
- 代谢疾病在美国移民群体中普遍存在, 原因不明.
- 肠道微生物在代谢疾病中的作用已确立,但移民的影响尚未研究.
研究的目的:
- 研究美国移民对肠道微生物组合和功能的影响.
- 了解移民如何影响微生物多样性和新陈代谢健康.
主要方法:
- 收集泰国和美国的赫蒙族和卡伦族人的便,饮食和人体数据.
- 使用16S和深度猎枪的基因组测序进行微生物组分析.
- 包括第一代和第二代移民,移民前和移民后的个人,以及美国出生的对照.
主要成果:
- 移民美国导致肠道微生物群的多样性和功能立即丧失.
- 美国相关的微生物菌株和功能在移民后取代了本地菌株.
- 这些变化随着居住在美国的时间,肥胖和几代人而加剧.
结论:
- 美国移民严重破坏了肠道微生物群.
- 微生物组的变化与居住时间,肥胖和代际影响有关.
- 研究结果强调肠道微生物群是移民代谢疾病的一个因素.
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