自通过循环的阿尔金因维持瘤的生长
Laura Poillet-Perez1, Xiaoqi Xie1, Le Zhan1
1Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Nature
|November 16, 2018
概括
主体自通过维持氨酸水平来支持癌症. 在宿主中阻断自会释放肝脏的阿尔基纳I, 耗尽阿尔基尼和饥饿瘤. 恢复氨酸部分挽救了瘤的生长.
科学领域:
- 细胞生物学
- 代谢过程
- 癌症生物学
背景情况:
- 自对于细胞代谢和生存至关重要,特别是在营养缺乏期间.
- 癌细胞利用自生长和生存,但宿主自在瘤进展中的作用是复杂的.
- 系统性删除小鼠的自基因会影响新陈代谢和瘤生长,这表明宿主自的作用.
研究的目的:
- 调查宿主自对瘤生长的影响.
- 确定宿主自会影响瘤进展的代谢机制.
- 探索针对癌症宿主自的潜在治疗策略.
主要方法:
- 在成年小鼠中,主体特异性缺失重要的自基因 (Atg7,Atg5).
- 瘤移植和瘤生长的评估.
- 血清蛋白质组分析和体内阿基因的代谢追踪.
- 饮食补充剂与阿尔金因.
主要成果:
- 宿主特异性的Atg7缺失影响了多种移植瘤的生长.
- 主体自的丧失导致了循环中阿尔金因水平的降低和循环中阿尔金酶I (ARG1) 的增加.
- 肝脏特异性的Atg7缺失模仿了这些效应,而阿尔金因补充剂部分恢复了瘤的生长.
结论:
- 缺陷的宿主自会导致肝脏释放ARG1, 降低循环中对瘤生长至关重要的氨酸.
- 这表明了癌症的代谢脆弱性, 主体自通过维持氨酸供应来支持瘤的进展.
- 针对宿主自或阿尔金因代谢为癌症治疗提供了潜在的治疗途径.
相关概念视频
Autophagy
5.9K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.9K
Coronary Circulation
7.3K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.3K
Fetal Circulation
3.0K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
3.0K
Design Example: Maintaining Level of an Embankment
435
Constructing a roadway embankment over uneven terrain requires precise leveling to ensure stability and proper drainage. Surveyors use a leveling instrument and staff to calculate ground elevations and determine the required fill material at each point along the embankment alignment.The process begins by positioning a leveling instrument near a benchmark with a known elevation. A backsight reading establishes the instrument height, which serves as a reference for subsequent measurements. A...
435
Overview of Pulmonary Circulation
3.1K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
3.1K
Role of Vitamins in Maintaining Bone Health
5.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.5K


