海米马斯蒂戈福拉是一种新型超王国级的真核生物系
Gordon Lax1, Yana Eglit1, Laura Eme2,3
1Department of Biology, Centre for Comparative Genomics and Evolutionary Bioinformatics, Dalhousie University, Halifax, Nova Scotia, Canada.
Nature
|November 16, 2018
概括
研究人员已经将独特的Hemimastigophora群,以前未被分配,作为一个独立的超王国血统. 这一发现重新塑造了我们对真核生物进化和最后一个真核生物共同祖先的理解.
科学领域:
- 细胞进化
- 抗菌学
- 分子遗传学
背景情况:
- 大多数真核生物被基因分类,但Hemimastigophora仍然没有被分配.
- 半虫是具有独特细胞结构的形态上独特的掠食性原生动物.
- 此前没有Hemimastigophora的分子数据或培养.
研究的目的:
- 确定Hemimastigophora在真核生命树中的遗传位置.
- 调查Hemimastigophora的进化意义,以了解深层真核生物的分歧.
- 为未来的基因组和细胞生物学研究建立一个可培养的模型.
主要方法:
- 使用高覆盖率,独立于种植的转录组分析.
- 与已确定的真核生物超群进行比较分析.
- 建立第一个Hemimastigote培养 (Hemimastix kukwesjijk sp. 没有.
主要成果:
- 在所有已建立的真核超群之外.
- 这种血统形成了一个独立的超王国级别群体.
- 它可能是"Diaphoretickes"超级群的姐妹类,影响真核树拓.
- 第一个Hemimastix kukwesjijk的培养成功建立.
结论:
- 海米马斯蒂戈福拉 (Hemimastigophora) 是一个主要的,以前未被认可的真核生物进化系.
- 它的基因组定位需要重新评估真核生物的分类和深度进化历史.
- 这种新文化为未来关于真核生物起源和最后一个真核生物共同祖先的研究提供了重要资源.
相关概念视频
The Tree of Life - Bacteria, Archaea, Eukaryotes
38.4K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
38.4K
Replication in Eukaryotes
204.8K
Overview
204.8K
Replication in Eukaryotes
17.4K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
17.4K
The Eukaryotic Promoter Region
18.8K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences. The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.8K
Eukaryotic RNA Polymerases
27.1K
RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
All three eukaryotic RNAPs require specific transcription factors, of which the...
All three eukaryotic RNAPs require specific transcription factors, of which the...
27.1K
Lineage Commitment
4.4K
Commitment is the process whereby stem cells:
4.4K


