海马对于在睡眠期间形成非海马长期记忆至关重要
Anuck Sawangjit1, Carlos N Oyanedel1,2, Niels Niethard1
1Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany.
Nature
|November 16, 2018
概括
即使是被认为独立于海马的记忆也能从睡眠中获益, 这项研究揭示海马体在睡眠期间固化非海马体依赖的记忆至关重要.
科学领域:
- 神经科学
- 认知科学
- 记忆研究
背景情况:
- 记忆大致分为依赖海马和非依赖海马的类型.
- 睡眠有助于巩固依赖于海马的记忆.
- 睡眠在巩固非海马体依赖的记忆中的作用仍然不太清楚.
研究的目的:
- 调查睡眠和海马体机制对于非海马体依赖的长期记忆的必要性.
- 要确定海马体依赖的机制是否参与非海马体依赖的记忆的睡眠依赖巩固.
主要方法:
- 鼠被训练在新的物体识别 (非海马体依赖) 和物体位置识别 (海马体依赖) 任务上.
- 在编码后的睡眠或清醒时间为2小时.
- 通过在特定时间内注射肌肉醇来操纵海马功能.
- 在即时和远程 (1-3周) 时间点评估记忆性能.
主要成果:
- 对象位置识别记忆在即时和远程测试中都显示了睡眠的好处.
- 新的物体识别记忆仅在远程测试 (3周) 中显示了睡眠效益.
- 在编码后的睡眠中使海马体不活化, 消除了睡眠诱导的远程新物体识别记忆.
结论:
- 海马体在长期依赖睡眠巩固甚至非海马体依赖记忆中起着至关重要的作用.
- 睡眠中的神经元重复,特别是螺旋活动,可能是巩固过程的基础.
- 这挑战了传统的记忆系统二分法,并突出了海马在记忆巩固中的更广泛作用.
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