改善的埃及基因组提供了对 arbovirus 载体的控制信息
Benjamin J Matthews1,2,3, Olga Dudchenko4,5,6,7, Sarah B Kingan8
1Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY, USA. bnmtthws@gmail.com.
Nature
|November 16, 2018
概括
对埃及蚊子 (AaegL5) 的新基因组组显著推进了疾病传播的研究. 这种改进的组合有助于了解蚊子的生物学,并开发针对危险病毒病原体的新策略.
科学领域:
- 基因组学
- 载体生物学
- 医学昆虫学
背景情况:
- 蚊子会传染多种病毒性疾病,包括登革热,黄热病,寨卡病毒和 chikungunya, 每年超过4亿人受到影响.
- 高质量的基因组组装对于推进蚊子生物学和控制策略的研究至关重要,但以前的组装是有限的.
研究的目的:
- 制造出Aedes aegypti (AaegL5) 的显著改进和完全重新注释的基因组组.
- 展示 AaegL5 组件如何加速科学理解和对这种疾病载体的干预策略的开发.
主要方法:
- 整合多种基因组技术来创建AAEGL5组件.
- 将物理和细胞遗传地图固定在新组件上.
- 使用高分辨率的定量特征位点和种群基因组分析.
主要成果:
- 该AAegL5组件提供了明显改善的,完全重新注释的基因组.
- 已知化学感应离子受体的数量翻了一番, 并提供了关于性别决定的M位点的见解.
- 揭示了与杀虫剂耐药性相关的谷氨S转移酶基因的拷贝数变异,并绘制了新的载体能力候选者.
结论:
- 该AAegL5基因组组合是一个强大的工具,将加速对Aedes aegypti的生物学见解.
- 这种资源将有助于开发新的干预策略,以打击蚊子传播的病毒性疾病的传播.
相关概念视频
Genomics
40.7K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.7K
Inertial Frames of Reference
8.8K
Newton’s first law is usually considered to be a statement about reference frames. It provides a method for identifying a special type of reference frame: the inertial reference frame. In principle, we can make the net force on a body zero. If its velocity relative to a given frame is constant, then that frame is said to be inertial. So, by definition, an inertial reference frame is a reference frame where Newton's first law holds valid. Newton's first law applies to objects with...
8.8K
Non-inertial Frames of Reference
7.2K
A reference frame accelerating or decelerating relative to an inertial frame is a non-inertial frame. To help understand this, consider what taking off in an airplane, turning a corner in a car, riding a merry-go-round, and the circular motion of a tropical cyclone all have in common. All these systems are accelerating, decelerating, or rotating relative to the Earth; hence, they all are non-inertial frames. All these systems exhibit inertial forces, which merely seem to arise from motion,...
7.2K
Chemical Shift: Internal References and Solvent Effects
1.4K
In an NMR sample, precise measurement of the absolute absorption frequencies of nuclei is difficult. A standard internal reference compound is added, and the frequency difference between the reference signal and sample signals is measured.
The internal reference compound generally used in NMR spectroscopy is tetramethylsilane (TMS). TMS is preferred because it is chemically inert, soluble in NMR solvents, and easily removable. Also, the highly shielded methyl protons in TMS yield an intense...
The internal reference compound generally used in NMR spectroscopy is tetramethylsilane (TMS). TMS is preferred because it is chemically inert, soluble in NMR solvents, and easily removable. Also, the highly shielded methyl protons in TMS yield an intense...
1.4K
Genomic Imprinting and Inheritance
37.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.2K
Genome Size and the Evolution of New Genes
9.1K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.1K


