诱导自主记忆膜巨细胞需要T细胞的帮助,对训练免疫力至关重要
Yushi Yao1, Mangalakumari Jeyanathan1, Siamak Haddadi1
1McMaster Immunology Research Centre, M. G. DeGroote Institute for Infectious Disease Research, & Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, L8S 4K1, Canada.
Cell
|November 16, 2018
概括
呼吸道病毒感染会产生长期记忆的肺膜巨细胞 (AMs),增强肺部免疫力. 这些由T细胞启动的记忆AM为随后的细菌感染提供训练有素的免疫力.
科学领域:
- 免疫学
- 天生的免疫力
- 适应性免疫力
背景情况:
- 遗传免疫记忆是一个新兴领域.
- 了解粘膜部位的先天免疫记忆是有限的.
研究的目的:
- 在呼吸道病毒感染后,研究膜巨细胞 (AMs) 的先天免疫记忆.
- 阐明记忆AM形成和功能中的机制和适应性免疫细胞参与.
- 确定记忆AM在对二次细菌感染的训练免疫力中的作用.
主要方法:
- 在小鼠模型中诱导呼吸道病毒感染.
- 使用转录组学,流细胞计和代谢试验对膜巨细胞进行表征.
- 进行T细胞消耗和收养转移实验.
- 评估二次细菌感染的结果.
主要成果:
- 呼吸道病毒感染诱导长期记忆AMs,其特征是高MHC II表达,防御准备的基因特征和增强的糖分代谢.
- 记忆AMs被编程在重新刺激时产生中性粒细胞化学因子.
- 记忆AMs的初始化需要效应性CD8T细胞及其IFN-γ的产生,但它们的维持是独立于单细胞或原始细胞的.
- 通过快速诱导化学因子和中性友好性,记忆AM赋予了对肺部细菌感染的训练免疫力.
结论:
- 呼吸道病毒感染在膜巨细胞中建立长期的先天免疫记忆.
- 适应性T细胞对于启动记忆AMs至关重要, 建立了适应性和先天性免疫之间的联系.
- 记忆增强剂可增强对二次细菌感染的保护,突出显示了免疫记忆的新范式.
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