在酵母生物杂交中以光驱动的精细化学品生产
Junling Guo1, Miguel Suástegui1, Kelsey K Sakimoto2,3
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. junling.guo@wyss.harvard.edu neel.joshi@wyss.harvard.edu.
概括
这项研究介绍了一种使用化物纳米粒子和人工酵母进行可持续化学合成的新型生物无机混合平台. 这种系统通过光驱动的辅因子再生有效地产生有价值的制药前体石胺酸.
科学领域:
- 生物技术
- 材料科学
- 合成生物学
背景情况:
- 无机生物混合系统通过将半导体光采集与细胞代谢能力相结合,提供可持续和高效的化学合成.
- 开发这种混合系统对于推进生物制造和创建新型生产平台至关重要.
研究的目的:
- 创建一个模块化生物无机混合平台,将化物纳米颗粒与工程Saccharomyces cerevisiae集成.
- 展示该平台的光驱辅助因子再生能力和高效的代谢物生产.
主要方法:
- 使用高效的聚光纳米粒子.
- 用于生物催化剂的转基因细菌 (酵母).
- 集成纳米粒子光采集与酵母细胞系辅因子再生途径.
主要成果:
- 生物无机混合系统成功地从纳米粒子中收集了光生成的电子.
- 工程酵母利用这些电子进行细胞解氧因子再生.
- 实现了碳和能源效率高的石化酸生产,石化酸是药物和精细化学品的关键前体.
结论:
- 开发的平台可使生物合成和辅助因子再生脱,提高工艺效率.
- 这种生物混合方法为设计复杂和功能性的生物制造过程提供了多功能平台.
- 强调将无机纳米材料与微生物工程融合为可持续化学生产的潜力.
相关概念视频
Yeast Signaling
17.3K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
17.3K
Fineness of Cement
518
The fineness of cement directly influences the rate of hydration, as the hydration begins at the surface of the cement particles. In addition to hydration, the fineness of cement is vital for various properties of concrete including workability, gypsum requirement, and long-term behavior. The fineness of cement is represented in terms of the specific surface of cement which is typically measured in square meters per kilogram, with several methods available for this determination.
Direct...
Direct...
518
Fineness Modulus
1.5K
The fineness modulus (FM) of aggregate is a numerical index that measures the coarseness or fineness of the particles. It is calculated by adding the cumulative percentages of aggregate retained on each of a specified series of sieves and dividing the sum by 100.
Consider performing sieve analysis on sand through a set of ASTM sieves. The weight of aggregate retained in each sieve and pan placed at the bottom is recorded, as given in Column B of Table 1.
To determine the fineness modulus of...
Consider performing sieve analysis on sand through a set of ASTM sieves. The weight of aggregate retained in each sieve and pan placed at the bottom is recorded, as given in Column B of Table 1.
To determine the fineness modulus of...
1.5K
Chemical Reactions
95.7K
A chemical reaction is a process by which the bonds in the atoms of substances are rearranged to generate new substances. Matter cannot be created or destroyed in a chemical reaction—the same type and number of atoms that make up the reactants are still present in the products. Merely, the rearrangement of chemical bonds produces new compounds.
Chemical Reactions Rearrange Atoms into New Substances
A chemical reaction takes starting materials—the reactants—and changes them...
Chemical Reactions Rearrange Atoms into New Substances
A chemical reaction takes starting materials—the reactants—and changes them...
95.7K
Chemical Equations
81.3K
Chemical equations represent the identities and relative quantities of substances involved in a chemical reaction. The substances undergoing reaction are called reactants, and their formulas are placed on the left side of the equation. The substances generated by the reaction are called products, and their formulas are placed on the right side of the equation. Plus signs (+) separate individual reactant and product formulas, and an arrow (→) separates the reactant and product (left and right)...
81.3K
Chemical Formulas
61.2K
A chemical formula presents information about the proportions of atoms constituting a particular chemical compound or molecule, mainly using symbols of elements and numbers. At times other symbols, such as dashes, parentheses, brackets, commas, plus, and minus signs, are also used. A chemical formula can be one of three types – molecular, empirical, and structural.
61.2K


