哺乳动物的非门德尔遗传非常有限
1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Cell
|November 17, 2018
概括
卡扎琴卡,贝尔托齐及其同事发现了鼠标基因组中的表观遗传变异性. 这种遗传现象影响了几代人的特征传播, 回答了有关其流行程度和影响的关键问题.
科学领域:
- 基因组学
- 表观遗传学
- 发育生物学
背景情况:
- 在基因相同的个体 (胞) 之间观察到了表观遗传的变异性,但理解不够.
- 这种表观遗传差异的流行率和跨代影响在很大程度上仍然是推测性的.
研究的目的:
- 在老鼠 littermates 中发现表观遗传变异的特定基因组元素.
- 研究这些可变表观遗传元素在世代内和跨世代的流行和表型后果.
主要方法:
- 跨鼠基因组的表观遗传标记的比较分析.
- 与已发现的表观遗传变异相关的表型传播的评估.
主要成果:
- 识别具有 littermates 之间显著表观遗传变异性的特定基因组区域.
- 证明表观遗传变异性与某些表型跨代传播之间的联系.
结论:
- 子中的表观遗传变异是一种可量化的现象,对遗传有影响.
- 这些发现为了解表观遗传差异如何促进表型多样性和遗传模式提供了基础.
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