进化以结束有毒关系:在细菌间的战争中ADP化
Elizabeth A Mueller1, Petra Anne Levin1
1Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA.
Cell
|November 17, 2018
概括
细菌在攻击其他细胞很久之前就开始争夺资源. 一项新的研究揭示了古老的细菌毒素可能是针对真核细胞的祖先.
科学领域:
- 微生物学
- 进化生物学
- 细菌致病性
背景情况:
- 细菌参与资源竞争,这是一个基本的生态驱动力.
- 针对真核细胞的细菌毒素是关键的毒性因素.
- 细菌毒素的进化起源尚未完全理解.
研究的目的:
- 确定参与细菌间竞争的新细菌参与者.
- 为了研究ADP-ribosyltransferase毒素的进化史.
主要方法:
- 对基因组进行比较分析.
- 遗传学研究
- 生物信息方法识别与毒素相关的基因.
主要成果:
- 发现了以前未知的细菌蛋白家族.
- 确定向真核细胞毒素的潜在进化前体.
- 证据表明特定的毒素家族的古代起源.
结论:
- 细菌之间的竞争推动了新型细菌武器的发展.
- 这些发现揭示了细菌毒素的早期演变.
- 鉴定到的参与者代表了我们对细菌战争的理解的重要补充.
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