化学稳固的MOF中的中孔是由减少连接性的大量顶点创建的
Qi Liu1,2, Yinyin Song1, Yanhang Ma3
1Key Laboratory of Biomedical Polymers-Ministry of Education, College of Chemistry and Molecular Sciences , Wuhan University , Luojiashan, Wuhan 430072 , China.
Journal of the American Chemical Society
|November 20, 2018
概括
我们通过使用一个短的有机链接器合成了两种新的金属有机框架 (MOF). MOF中的子大小由顶点数和连接性控制,使生物分子封装成为可能.
科学领域:
- 材料科学
- 化学学
- 纳米技术
背景情况:
- 金属有机框架 (MOF) 是具有可调节结构的多孔材料.
- 在药物输送和催化等应用中,设计具有较大的内腔的MOF至关重要.
- 控制MOF的子大小和稳定性仍然是一个重大挑战.
研究的目的:
- 报告两种新型MOF的合成,MOF-818和MOF-919,它们具有前所未有的中孔.
- 在MOF中研究连接器特性,顶点连接性和由此产生的子大小之间的关系.
- 评估合成的MOF的稳定性和潜在应用.
主要方法:
- 合成MOF-818和MOF-919使用二氧化物有机链接剂 (1H-pyrazole-4-carboxylic acid,H2PyC).
- 对MOF的结构进行表征,包括介质 (wuh,yys,liu) 和它们的尺寸的识别.
- 在MOF和超分子系统中对尺寸决定因素 (顶点数和连接性) 的系统分析.
主要成果:
- 成功合成了两个永久多孔的MOF,MOF-818和MOF-919.
- 确定了三种新的半孔 (wuh,yys,liu) 的直径为3.8nm,4.9nm和6.0nm.
- 子大小的延伸与顶点数相成比例,与顶点连接相反, [2-c,3-c] 连接对于大型子来说是最佳的.
- 最大的子 (liu) 实现了显著的子尺寸与链接器尺寸比率15.
- MOF-818在广泛的pH范围 (2-12) 中表现出稳定性,其可以容纳像维生素B12和胰岛素这样的生物分子.
结论:
- 通过控制顶点连接,该研究展示了在MOF中创建大型半孔的策略.
- 合成的MOF表现出极好的稳定性和封装大型生物分子的潜力.
- 这项工作提供了针对高级应用量身定制毛孔尺寸的MOF合理设计的见解.
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