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曼诺斯会阻碍瘤生长并增强化疗效
Pablo Sierra Gonzalez1, James O'Prey1, Simone Cardaci1,2
1Cancer Research UK Beatson Institute, Glasgow, UK.
Nature
|November 23, 2018
概括
曼诺糖会减缓瘤的生长,并增加癌细胞的死亡,尤其是在与化疗相结合时. 这种简单的糖疗法对各种癌症具有前景,并且与甘异构酶 (PMI) 水平有关.
科学领域:
- 癌症中的代谢途径
- 糖代谢和癌症
- 癌症治疗和耐药性
背景情况:
- 瘤表现出细胞代谢的改变, 呈现出潜在的脆弱性.
- 增加葡萄糖吸收是许多瘤类型的标志.
- 研究细胞对不同糖的反应可以揭示治疗点.
研究的目的:
- 研究单糖甘对瘤细胞生长和化疗反应的影响.
- 为了阐明曼诺抗瘤作用的潜在机制.
- 确定曼诺是否可以作为癌症治疗的有效策略.
主要方法:
- 在小鼠中使用各种瘤类型的体外和体内研究.
- 通过口服的曼诺和与化疗的结合.
- 糖解,TCA循环,酸途径和糖合成的代谢分析.
- 对抗亡蛋白水平和曼诺异构酶 (PMI) 活性进行评估.
- 对患者瘤样本中的PMI水平进行组织微阵列分析.
主要成果:
- 在体外和体内多种瘤类型中抑制生长并增强化疗诱导的细胞死亡.
- 曼诺以曼诺-6酸盐的形式积累,从而损害葡萄糖代谢和糖合成.
- 结合曼诺和化疗治疗会影响Bcl-2家族蛋白质,使细胞敏感到死亡.
- 瘤对曼诺斯的敏感性与曼诺斯异构酶 (PMI) 水平相反相关.
- 根据患者和瘤类型,PMI水平存在显著差异,这表明生物标志物的潜力.
结论:
- 曼诺斯通过破坏细胞代谢和使癌细胞对化疗敏感而表现出抗瘤特性.
- 曼诺斯治疗的疗效与曼诺斯异构酶 (PMI) 水平有关,这种水平可以作为预测生物标志物.
- 曼诺斯是一种潜在的简单,安全和选择性的治疗方法,用于各种癌症类型.
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