在Drosophila中,不同的活动通道介导着对CO2的吸引和厌恶
Floris van Breugel1,2, Ainul Huda1, Michael H Dickinson3
1California Institute of Technology, Pasadena, CA, USA.
Nature
|November 23, 2018
概括
果 (Drosophila) 在积极寻找食物时被二氧化碳 (CO2) 吸引,从而解决了它们的行为悖论. 这种吸引力是由IR25a受体介导的,与它们对乙醇的持续吸引力不同.
科学领域:
- 神经科学
- 动物的行为
- 嗅觉信号
背景情况:
- 二氧化碳是昆虫用来寻找宿主和食物的挥发性信号.
- 已知Drosophila melanogaster会消耗产生二氧化碳的酵母,但实验室研究表明它们避免使用二氧化碳.
- 这是一个关于二氧化碳在虫行为中的悖论.
研究的目的:
- 解决Drosophila melanogaster中二氧化碳吸引和厌恶的悖论.
- 研究行为状态在二氧化碳检测和反应中的作用.
- 确定参与二氧化碳吸收的嗅觉受体.
主要方法:
- 在飞行和行走的Drosophila中测量对二氧化碳和乙醇的吸引力和厌恶性的行为测试.
- 用于评估特定嗅觉受体的功能,包括IR25a.
- 对不同行为状态的反应进行比较 (积极食与低活动).
主要成果:
- 当它们处于活跃的食状态时,它们会被二氧化碳吸引,但当它们处于不活跃状态时,它们会避开二氧化碳.
- 乙醇在所有行为状态中都对Drosophila具有吸引力,其偏好比CO2更强.
- 离子同受体IR25a对于吸引二氧化碳至关重要,而二氧化碳回避机制是不同的.
结论:
- 草对二氧化碳的反应取决于它们的食活动.
- 在Drosophila中,IR25a在吸引二氧化碳方面发挥着关键作用.
- 这项研究提供了依赖于状态和气味的决策的神经基础.
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