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相关概念视频

Crossing Over01:34

Crossing Over

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Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
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Crossing Over01:30

Crossing Over

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Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
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Monohybrid Crosses01:20

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Overview
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Cross-Sectional Research01:50

Cross-Sectional Research

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In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
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Test Cross01:39

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Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.
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立体指导 C ((sp3) -S 交叉合

Feng Zhu1, Eric Miller1, Shuo-Qing Zhang2

  • 1Department of Chemistry , University of Colorado , Boulder , Colorado 80309 , United States.

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|November 27, 2018
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概括

这项研究引入了合成硫糖化物和糖多样化的立体交叉合反应. 铜促进方法为后期应用提供受控的碳硫键形成.

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科学领域:

  • 有机化学
  • 碳水化合物化学
  • 生物结合化学

背景情况:

  • 对于药物发现而言,有效的硫糖化物和糖合成至关重要.
  • 复杂分子的后期功能化仍然是合成化学的一个重大挑战.

研究的目的:

  • 开发一种形成碳-硫键的立体交叉合反应.
  • 证明这种方法在合成硫糖化物和糖多样化中的实用性.

主要方法:

  • 核与二硫化物和N-硫糖胺捐赠物的铜 (I) 促进的交叉合.
  • 使用具有共同保护群的碳水化合物基质和具有自由基/胺基功能的.
  • 使用竞争实验和计算DFT研究来阐明反应机制.

主要成果:

  • 从基/基醇和基化物中实现立体化合成.
  • 在中成功进行了囊残留的糖分多样化.
  • 确定了一个结构稳定,寿命短的器官铜中间体,耐表化.

结论:

  • 开发的糖交叉合反应对晚期糖多样化和生物结合非常有效.
  • 该方法允许在温和条件下控制安装碳硫键.
  • 反应的立体性质归因于快速且非缩小的消除步骤.