奖励行为是由海马核和腹突触的强度调节的
Tara A LeGates1, Mark D Kvarta1,2, Jessica R Tooley3
1Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Nature
|November 28, 2018
概括
长期增强 (LTP) 在海马核突触 (NAc) 驱动奖励相关的行为. 而抗抑郁药可以扭转这些效应.
科学领域:
- 神经科学
- 行为神经科学
- 突触可塑性
背景情况:
- 奖励处理对于生存和动机行为至关重要.
- 奖励途径的失调与成和抑郁症 (无情感) 等疾病有关.
- 对于奖励相关活动而言,海马体输入到核 (NAc) 贝至关重要.
研究的目的:
- 研究海马-NAc突触的长期增强机制 (LTP).
- 确定这个部位的突触可塑性是否有助于奖励相关的行为.
- 研究慢性压力和抗抑郁药对海马-NAc突触可塑性和奖励行为的影响.
主要方法:
- 在小鼠中使用高频刺激诱导海马-NAc突触的LTP.
- 作为奖励行为的衡量标准的条件位置偏好 (CPP) 的评估.
- 在慢性压力和抗抑郁药物治疗后评估突触强度和LTP.
主要成果:
- 在海马-NAc突触中诱导多巴胺独立的LTP.
- 这些突触的LTP诱导驱动了条件位置偏好 (CPP).
- 慢性压力降低了突触强度和LTP受损,而抗抑郁药物治疗逆转了这些变化.
结论:
- 海马-NAc突触表现出活动依赖的可塑性.
- 在海马-NAc突触的突触强度对于上下文奖励行为至关重要.
- hippocampus-NAc 突触可塑性的调节可能是无情症的治疗点.
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