马克罗巴 (Macropa) 通过BaSO的快速溶解,这是一个18个成员的宏循环,对Ba2有很高的亲和力
Nikki A Thiele1, Samantha N MacMillan1, Justin J Wilson1
1Department of Chemistry and Chemical Biology, Baker Laboratory , Cornell University , Ithaca , New York 14853 , United States.
Journal of the American Chemical Society
|November 29, 2018
概括
一个新的连接体,macropa,有效化离子 (Ba2+) 并溶解硫酸盐 (BaSO4). 与现有方法相比,这一突破为石油行业管道堵塞提供了更有效的解决方案.
科学领域:
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
- 环境科学 环境科学
背景情况:
- 硫酸 (BaSO4) 垢形成在石油工业中带来了重大运营挑战和成本.
- 现有的合剂对Ba2+的亲和力较低,因此需要严苛的条件来溶解BaSO4度.
- 为了有效地去除BaSO4,需要对Ba2+具有高结合亲和力的配体.
研究的目的:
- 为了研究Ba2+化新型的Diaza-18-crown-6宏循环.
- 评估这些宏循环在溶解BaSO4中的有效性.
- 为了确定工业应用的优质合剂.
主要方法:
- 三个diaza-18-crown-6宏循环的合成和表征,具有不同的悬臂.
- 在中性pH下评估Ba2+结合亲和力.
- 在温和条件下评估BaSO4溶解效率 (室温,pH8).
- 与最先进的合剂,如DTPA和DOTA进行比较.
主要成果:
- 双皮科林酸联体,macropa,在pH值7.4.4时表现出对Ba2+ (log K' = 10.74) 报告的最高亲和力.
- 马克罗巴在室温和pH值8.8的情况下,在30分钟内实现了BaSO4的完全溶解.
- 马克罗巴显著优于DTPA和DOTA,在相同的条件下,它们只能达到40%的溶解.
- 马克罗巴还在溶解天然巴里特样品方面表现出卓越的表现.
结论:
- 麦克罗帕是Ba2+的高效化剂,形成了一个动力稳定的复合体.
- 麦克罗帕在温和条件下提供了一种更有效的BaSO4溶解方法.
- 马克罗巴显示出在石油生产和规模整治中的工业应用的巨大潜力.
相关概念视频
Electron Affinity
43.3K
The electron affinity (EA) is the energy change for adding an electron to a gaseous atom to form an anion (negative ion).
43.3K
Affinity and Avidity
39.0K
Overview
39.0K
Five-Membered Heterocyclic Aromatic Compounds: Overview
5.4K
Heterocyclic aromatic compounds are cyclic compounds that are aromatic and have one or more heteroatoms—atoms other than carbon, in the ring. Depending upon the number of atoms present in the ring, they can be either five or six-membered. Examples of five-membered heterocyclic aromatic compounds include pyrrole, furan, thiophene, and imidazole. Pyrrole consists of one nitrogen atom having one lone pair of electrons. Furan and thiophene have one oxygen and one sulfur heteroatom,...
5.4K
Affinity Chromatography
3.0K
Affinity chromatography is a powerful technique extensively utilized for separating and purifying specific biomolecules from complex mixtures. It capitalizes on the highly selective binding between an analyte and its counterpart, such as antibody-antigen interactions. The counterpart is immobilized on the stationary phase, forming an affinity column. The stationary phase typically consists of solid support, such as agarose or porous glass beads, immobilizing the affinity ligand. The mobile...
3.0K
In Vitro Drug Dissolution: Alternative Methods
234
Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
234
Theories of Dissolution: Diffusion Layer Model
1.8K
Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
1.8K

![Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F2755.jpg&w=3840&q=50)
