纳米级金属有机层用于放射疗法-放射动力疗法
Journal of the American Chemical Society
|November 29, 2018
概括
两个新的纳米金属有机层 (nMOLs),Hf12-Ir和Hf6-Ir,显示出强大的抗癌作用. 这些材料增强了放射治疗和放射动力学治疗,导致99%以上的瘤回归,使用低X射线剂量.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 纳米金属有机层 (nMOLs) 是由纳米金属有机框架 (nMOFs) 衍生的新兴的二维晶体材料.
- nMOLs提供可调节的结构和组合,结合2D纳米材料的异构性质,使它们成为生物医学用途的前景.
- 放射治疗 (RT) 和放射动力疗法 (RDT) 是癌症治疗的关键方法.
研究的目的:
- 为联合RT和RTD应用开发新的nMOL.
- 为了研究Hf12-Ir和Hf6-Ir nMOLs的抗癌疗效.
- 探索通过这些nMOLs来加强RT和RTD的行动机制.
主要方法:
- 合成了两种新的nMOLs,Hf12-Ir和Hf6-Ir,利用Hf12和Hf6的二次构建单元 (SBU) 和光敏感化基联体.
- 用Hf12-Ir和Hf6-Ir治疗的癌细胞的X射线照射.
- 在X射线曝光时对反应性氧物种 (ROS) 产生 (基激素,单片氧,超氧化离子) 的分析.
- 评估癌细胞死亡 (通过RDT即时死亡,通过RT生殖死亡) 和瘤回归 in vivo.
主要成果:
- Hf12-Ir和Hf6-Ir有效地吸收了X射线,增强了RT和RDT.
- 对nMOLs的X射线辐射产生基基 (RT增强) 和激发的联体,产生单片氧和超氧化离子 (RDT激活).
- 通过RDT和RT,nMOLs诱导了显著的癌细胞死亡,在低X射线剂量 (0.5 × 5 Gy) 下实现了>99%的瘤回归.
结论:
- Hf12-Ir和Hf6-Ir代表了用于协同癌症治疗的新一类2D纳米材料.
- 这些nMOL有效地结合了RT和RDT,为增强抗癌疗效提供了一个有希望的策略.
- 开发的nMOL显示出低剂量,高效的癌症治疗潜力,副作用最小.
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