通过分子基前体的模块化合成实现的合成和光谱研究
Wesley J Transue1, Junyu Yang1, Matthew Nava1
1Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
Journal of the American Chemical Society
|November 29, 2018
概括
新的二-7-甲化合物通过热分解产生有价值的基替代基. 这项研究详细介绍了它们的合成和特征,包括对基因性质的新光谱见解.
科学领域:
- 有机化学
- 合成有机化学
- 光谱学
背景情况:
- 基因 (RCP) 是含有的反应性基因类型.
- 由于不稳定性,它们的合成和分离可能具有挑战性.
- Dibenzo-7-phosphanorbornadienes提供了基因前体的潜在途径.
研究的目的:
- 合成和表征一系列的二-7-化化合物.
- 研究这些前体的热碎片化,以产生基替代基.
- 探索由此产生的素素的光谱性质,包括新的NMR测量.
主要方法:
- 通过ClPA与化物反应合成二-7-甲前体.
- 定量 31P 核磁共振光谱测量素产量.
- 耳环分析研究单分子碎片化的动力学.
- 溶液核磁共振和气相旋转微波光谱用于素基因的检测和表征.
主要成果:
- 通过各种基替代物 (R = Me,Et,Ipr,sBu) 成功合成二-7-基甲基化合物.
- 在热分解过程中,基替代基因的转化率为56-73%,R=Me,Et,iPr.
- 通过NMR和微波光谱直接检测和表征1-素 (MeCP).
- 对基因的-31核旋转合张量进行首次测量.
结论:
- Dibenzo-7-phosphanorbornadienes是通过热分裂生成基替代基的有效前体.
- 这项研究为这些重要的有机化合物提供了可行的合成途径.
- 新的光谱数据,包括P-31旋转合,提高了对素电子结构和结合的理解.
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