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相关概念视频

The Evidence for Evolution02:55

The Evidence for Evolution

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Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
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Convergent Evolution01:54

Convergent Evolution

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Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
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Eukaryotic Evolution01:24

Eukaryotic Evolution

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The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
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Synteny and Evolution02:31

Synteny and Evolution

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John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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相关实验视频

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Molecular Evolution of the Tre Recombinase
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让进化论发挥作用

Rama Ranganathan1

  • 1Center for Physics of Evolving Systems, Department of Biochemistry & Molecular Biology, The Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.

Cell
|December 1, 2018
PubMed
概括
此摘要是机器生成的。

三位科学家因在蛋白质工程中使用实验室进化获得诺贝尔化学奖. 这种突破性的技术通过定向进化加速了新型蛋白质的设计.

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科学领域:

  • 生物化学
  • 分子生物学
  • 蛋白质工程

背景情况:

  • 2018年诺贝尔化学奖是为了表彰蛋白质工程的进步.
  • 弗朗西斯·阿诺德,乔治·P·史密斯和格雷戈里·P·温特爵士开创了实验室进化技术.

研究的目的:

  • 突出实验室进化对蛋白质工程的重要性.
  • 强调这些方法对各种应用的影响.
  • 激发对分子设计进化原理的进一步研究.

主要方法:

  • 实验室进化的应用 (定向进化) 用于蛋白质工程.
  • 使用菌体显示等技术进行蛋白质进化.
  • 突变,选择和选的反复循环.

主要成果:

  • 成功设计具有新和增强功能的蛋白质.
  • 开发强大的蛋白质设计和发现工具.
  • 证明实验室进化在不同领域的广泛适用性.

结论:

  • 实验室进化是蛋白质工程中的一个变革性方法.
  • 这些方法为创建定制蛋白质提供了强大的平台.
  • 定向进化的原则为一般设计策略提供了洞察力.