秘:一个古老的激素与一个燃烧的秘密
Randall L Mynatt1, Eric Ravussin1
1Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
Cell
|December 1, 2018
概括
这是一种肠道激素,在饭后刺激棕色脂肪组织的热生成. 这一发现揭示了 секре因调节和能量消耗的新机制.
科学领域:
- 内分泌学
- 代谢过程
- 神经科学
背景情况:
- 食物诱导的热生成通常由肠-大脑-棕色脂肪组织 (BAT) 轴解释.
- 这个轴通过同情神经系统调节热生成.
研究的目的:
- 调查分泌素在食诱导的热生成中的作用.
- 确定调节和能量消耗的新机制.
主要方法:
- 研究了分泌素与棕色脂肪组织的受体的结合.
- 评估了分泌素对热生成和食物摄入的影响.
主要成果:
- 饮食后由肠道释放的秘与BAT中的受体结合.
- 在BAT中,分泌素直接刺激热生成.
- 施用Secretin可以抑制食物摄入.
结论:
- 它通过棕色脂肪组织刺激热生成.
- 秘作为一种新的腹调节剂,影响食物摄入.
- 这一发现为肠-大脑-BAT轴在新陈代谢调节方面提供了新的视角.
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