在肺部训练免疫和局部先天免疫记忆
Mihai G Netea1, Leo A B Joosten2
1Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
Cell
|December 1, 2018
概括
经过训练的免疫力通过表观遗传重新编程来保护. 一项新的研究表明病毒感染会在肺部巨细胞中局部诱导这种情况,由CD8+ T细胞信号发出.
科学领域:
- 免疫学
- 传染性疾病
- 表观遗传学
背景情况:
- 经过训练的天生的免疫力通过表观遗传修饰提供了对各种病原体的广泛保护.
- 这种现象涉及到骨髓细胞及其前体的功能重编程.
研究的目的:
- 专门研究肺微环境中训练免疫的诱导.
- 鉴定病毒感染后驱动局部训练免疫力的细胞和分子机制.
主要方法:
- 在小鼠中的病毒感染模型.
- 对大胞细胞重编程的分析.
- 评估CD8+T细胞参与和细胞因子释放 (IFNγ).
主要成果:
- 病毒感染触发了膜巨细胞的训练免疫力.
- 由效应体CD8+T淋巴细胞释放的干扰素 (IFNγ) 被确定为一个关键的启动剂.
- 肺部骨髓细胞的表观遗传和功能重编.
结论:
- 病毒感染可以在肺部引起局部形式的训练免疫.
- 效应体CD8+ T细胞和IFNγ在启动这种局部训练免疫反应方面发挥着至关重要的作用.
- 突出了肺系统中的免疫记忆机制.
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