通过TbGPR89传递的寡信号驱动了三体质量检测
Federico Rojas1, Eleanor Silvester1, Julie Young1
1Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, UK.
Cell
|December 4, 2018
概括
三生体使用定数感应 (QS) 触发形的发展. 一种与G蛋白结合的受体89 (GPR89) 蛋白接收信号,它是一种寡,可使寄生虫传播.
科学领域:
- 寄生虫学
- 分子生物学
- 生物化学
背景情况:
- 三子体通过定数感应 (QS) 调节毒性和传播.
- 目前尚不清楚三子体中的型诱导因子 (SIF) 信号及其接收机制.
- 三子体缺乏正规的G蛋白合受体 (GPCR) 信号通路.
研究的目的:
- 在Trypanosoma brucei中识别SIF信号及其接收机制.
- 阐明QS介导的形差异化的分子基础.
主要方法:
- 在三子体中识别和描述一种新型GPR89家族蛋白质.
- 在细菌和三体中TbGPR89的功能表达.
- TbGPR89的结构建模和与寡载体 (POT) 的比较.
- 在体外和体内测试以评估寡和TbGPR89在树形成中的作用.
主要成果:
- 鉴定出了一种试体GPR89家族蛋白 (TbGPR89) 是形形成的关键调节者.
- TbGPR89与寡转运体具有结构上的相似性,并转运寡.
- 在试管体中表达大肠杆菌POT诱导的寄生虫分化.
- 在试验室中发现寡可促进的形成,而分泌的寡酶在体内产生了副信号.
结论:
- 在Trypanosoma brucei中,寡是SIF信号.
- TbGPR89作为质QS信号的受体,调解形的分化.
- 这一发现揭示了一种新的QS信号接收和产生的机制,影响了寄生虫的毒性和传播.
相关概念视频
Gene Regulation in Microbial Communities: Quorum Sensing
605
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
605
Bacterial Signaling
40.7K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
40.7K
What is Cell Signaling?
130.4K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
130.4K
The Sense of Self: Reflected Self-Appraisal and Social Comparison
56.1K
According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.1K
Energy to Drive Translocation
2.8K
Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
Generally, polypeptides are unfolded by two distinct...
Generally, polypeptides are unfolded by two distinct...
2.8K
Introduction to Special Senses
7.5K
Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
7.5K


