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Dna2核酶缺陷导致染色体断裂的大型和复杂的DNA插入

Yang Yu1, Nhung Pham1, Bo Xia2,3,4

  • 1Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, USA.

Nature
|December 7, 2018
PubMed
概括

缺乏Dna2核酶的酵母突变经常将DNA片段插入双链断裂 (DSB). 这些来自不同基因组区域的插入代表了依赖于非同类末端连接和Pol4的重复.

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