从海马CA2到侧面隔膜的电路可以消除社会攻击
Felix Leroy1, Jung Park2, Arun Asok2
1Department of Neuroscience, The Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. felxfel@aol.com.
Nature
|December 7, 2018
概括
在海马CA2区域的金字塔神经元促进社会攻击性. 这种途径涉及横隔膜和氨酸压缩素, 影响动机行为.
科学领域:
- 神经科学
- 行为神经科学
- 神经生物学
背景情况:
- 河马对于声明性记忆至关重要.
- 它在调节动机行为中的作用,
研究的目的:
- 研究海马CA2区域在促进社会攻击中的作用.
- 解释这种行为背后的神经回路和分子机制.
主要方法:
- 在小鼠的电生理记录.
- 通过光遗传和化学遗传对神经回路进行操纵.
- 对于社会攻击的行为测试.
- 药理干预向氨酸压缩素受体.
主要成果:
- 河马CA2神经元促进小鼠的社会攻击性.
- 在发作之前,侧隔膜的CA2输出会增强.
- 这种途径会抑制中腹下垂体, 引发攻击.
- 通过在侧隔膜中促进CA2突触传递,阿尔金压缩素增强了攻击性.
结论:
- 河马CA2到侧面隔膜电路对于社会攻击至关重要.
- 调节这种电路, 将内在状态与动机行为联系起来.
- 这种机制整合了社会记忆和侵略,
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