在支持生命的猪心脏外移植方面取得了持续的成功
Matthias Längin1,2, Tanja Mayr1,2, Bruno Reichart3
1Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
Nature
|December 7, 2018
概括
对需要心脏移植的患者来说, 基因改造的猪心脏是有希望的替代品. 这项研究在中实现了长期功能,
科学领域:
- 心血管外科
- 移植免疫学
- 异种移植研究
背景情况:
- 对于终极心力衰竭而言,
- 作为一种潜在的解决方案,正在探索从猪到灵长类动物的异种移植.
- 之前的异种移植显示了有限的长期生存和功能.
研究的目的:
- 评估基因改造的猪心脏在的长期形功能.
- 确定特定的保存和移植后管理是否确保了异种植的生存能力.
- 推进临床心脏外移植的临床前模型.
主要方法:
- 使用多种转基因猪心 (α1,3-银酸转移酶淘汰,表达人类CD46和血栓模块素).
- 使用连续 perfusion 的非缺血保存方法.
- 在中实施控制的移植后生长管理.
主要成果:
- 在身上实现了异种移植猪心的持续维持生命功能,长达195天.
- 证明了长期的正体功能,克服了以前的生存限制.
- 建立了一个严格的临床前模型来评估心脏外移植的可行性.
结论:
- 在特定的保存和管理下,基因改造的猪心可以在中实现长期的正体功能.
- 这是临床心脏外移植的重要里程碑.
- 这些发现支持异种移植有潜力解决器官短缺问题.
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