概括
在中风后,fluoxetine 没有改善功能结果. 虽然它减少了抑郁症,但它增加了骨折,因此不建议常规使用.
科学领域:
- 神经学
- 药理学
- 临床试验
背景情况:
- 之前的小型试验表明,素可能会增强中风后的功能恢复.
- FOCUS试验旨在精确评估这些潜在的益处.
研究的目的:
- 为了确定每日施用fluoxetine是否能改善急性中风后患者的功能结果.
- 评估fluoxetine对中风后抑郁和其他不良事件的影响.
主要方法:
- 一项实用,多中心,双盲,随机,安慰剂对照试验,涉及15天内3127名患者.
- 患者每天接受20毫克的fluoxetine或安慰剂6个月,使用修改的兰金尺度 (mRS) 评估功能状态.
主要成果:
- 在fluoxetine和安慰剂组之间没有显著的功能状态 (mRS) 差异 (p=0. 439).
- 西显著降低了新的抑郁症的发生率 (13. 43% 与 17. 21%, p=0. 0033).
- 素与骨折的发生率较高 (2. 88%与1. 47%,p=0. 0070).
结论:
- 在中风后的6个月内每天服用素并不能改善功能结果.
- 观察到的抑郁症的减少被骨折的风险增加所抵消.
- 目前的证据不支持在中风后进行功能恢复或抑郁症预防的常规使用.
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