化分子介导的多孔CuxO纳米颗粒集群具有抗氧化活性,可改善帕金森病
Changlong Hao1,2, Aihua Qu1,2, Liguang Xu1,2
1State Key Lab of Food Science and Technology , Jiangnan University , Wuxi , Jiangsu 214122 , People's Republic of China.
Journal of the American Chemical Society
|December 13, 2018
概括
统一的氧化铜纳米粒子集群有效地清除反应性氧物种,通过减少神经毒性和改善记忆力,为帕金森病提供一种新的治疗策略. 这种方法对神经疾病的治疗有前途.
科学领域:
- 纳米材料科学
- 神经科学
- 生物化学
背景情况:
- 由活性氧物种 (ROS) 驱动的线粒体功能障碍是帕金森病发病的一个关键因素.
- 为了预防与ROS相关的神经疾病,正在探索吸收ROS的无机纳米材料.
研究的目的:
- 合成和表征均的氧化铜 (CuxO) 纳米粒子集群 (NCs),模仿多种酶活动,用于帕金森病的潜在治疗应用.
- 在帕金森病模型中评估CuxONCs在缓解ROS诱导的神经毒性和挽救认知缺陷方面的有效性.
主要方法:
- 使用氨酸作为结构指导剂合成了统一的CuxO纳米粒子集群 (平均尺寸为65±7nm).
- 评估了CuxONCs的ROS清除活动,模仿过氧化酶,超氧化物脱氧化酶,酶和谷过氧化酶.
- 在细胞帕金森病模型中评估神经毒性,在帕金森病小鼠模型中评估记忆丧失.
主要成果:
- 合成的CuxO NCs表现出强大的ROS清除能力,模仿四种关键的抗氧化酶.
- 在帕金森病的细胞模型中,CuxONC有效抑制了神经毒性.
- 在患有帕金森病的小鼠中,使用CuxO NCs治疗挽救了记忆障碍.
结论:
- CuxO纳米粒子集群具有显著的生物相容性和多种酶模拟活动.
- 这些NC为帕金森病和相关神经疾病的治疗提供了有前途的新途径.
- 这些发现表明CuxONC在生物医学,生物传感和生物催化中具有广泛的潜在应用.
更多相关视频
10:44Preparation of Biomass-based Mesoporous Carbon with Higher Nitrogen-/Oxygen-chelating Adsorption for Cu(II) Through Microwave Pre-Pyrolysis
Published on: February 12, 2019
09:46Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles
Published on: August 26, 2018
相关概念视频
01:24Peroxisomes
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
01:17Oxidation of Phenols to Quinones
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...