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Divergence and Curl01:15

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The divergence of a vector field at a point is the net outward flow of the flux out of a small volume through a closed surface enclosing the volume, as the volume tends to zero. More practically, divergence measures how much a vector field spreads out or diverges from a given point. For an outgoing flux, conventionally, the divergence is positive. The diverging point is often called the "source" of the field. Meanwhile, the negative divergence of a vector field at a point means that the vector...
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The divergence and Stokes' theorems are a variation of Green's theorem in a higher dimension. They are also a generalization of the fundamental theorem of calculus. The divergence theorem and Stokes' theorem are in a way similar to each other; The divergence theorem relates to the dot product of a vector, while Stokes' theorem relates to the curl of a vector. Many applications in physics and engineering make use of the divergence and Stokes' theorems, enabling us to write...
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The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
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人类和大脑发育的时空转录分歧

Ying Zhu1,2, André M M Sousa1, Tianliuyun Gao1

  • 1Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA.

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概括
此摘要是机器生成的。

这项研究使用转录学绘制了物种间的大脑发育图,揭示了神经发育障碍的保存模式和基因联系. 这些发现揭示了人类大脑的演变和疾病的起源.

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科学领域:

  • 神经科学
  • 基因组学
  • 发育生物学

背景情况:

  • 人类神经系统的发展是复杂的,需要精确的基因调节.
  • 了解跨物种的保存发育模式对于对人类大脑进化和疾病的洞察至关重要.

研究的目的:

  • 调查灵长类大脑发育 (产前和产后) 的转录学模式.
  • 识别跨物种和发育阶段的保存和分离的基因表达程序.
  • 探索人类大脑进化和神经精神疾病的遗传基础.

主要方法:

  • 来自16个 rhesus 大脑区域的组织水平和单细胞转录组数据.
  • 将的数据与人类的发展数据结合起来.
  • 分析了时空基因表达模式,并确定了不同的基因.

主要成果:

  • 在发育过程中和跨物种的转录组差异中确定了"杯状"模式,具有围产期的融合.
  • 在产前新皮层和产后大脑发育中的功能层次上观察到过渡的地形梯度.
  • 发现基因表达变化与产前皮层发育,自闭症谱系障碍和精神分裂症有关.

结论:

  • 转录组程序揭示了灵长类大脑发育的保存模式, 提供了对人类大脑进化的见解.
  • 特定的基因表达变化与不同大脑区域的发展和神经精神疾病的发病有关.